The Penrith Panthers face the Rabbitohs in a crucial top-four clash at CommBank Stadium.
The Panthers will be without Isaah Yeo, Liam Martin, and Nathan Cleary due to Origin duties.
Experts remain divided, with some favoring the form of the Rabbitohs while others highlight the Panthers' strength.
Tactical control of the game through outside backs is expected to be a major factor in the final result.