The first T20 match between India and England faces an 80% risk of rain disruption at Chester-le-Street.
Indian captain Shreyas Iyer leads the side aiming to bounce back after a series defeat against Ireland.
Speculation surrounds the potential international debut of 15-year-old batting sensation Vaibhav Suryavanshi.
England has confirmed their playing XI, resting Jofra Archer while including Luke Wood and Saquib Mahmood.