England clinched a commanding 125-run win at Trent Bridge to take a 2-0 series lead.
Jofra Archer and Josh Tongue dismantled the Indian lineup, restricting them to just 76 runs.
Phil Salt anchored the English total of 201-7 with a composed 70 from 44 deliveries.
The defeat is the largest margin of loss for India in a T20 international.