Afghanistan wins the toss and chooses to bat first in the final ODI in Chennai.
India holds a 2-0 lead in the series following decisive wins in Lucknow and Dharmashala.
Both teams have made several lineup changes, including the return of Mohammad Nabi for Afghanistan and Nitish Kumar Reddy for India.
The match at MA Chidambaram Stadium is expected to be a high-scoring contest based on pitch conditions.